Information : Correlated electrostatic mutations provide a reservoir of stability in HIV protease
نویسندگان
چکیده
Supplementary Information: Correlated electrostatic mutations provide a reservoir of stability in HIV protease Omar Haq, Michael Andrec, Alexandre V. Morozov Ronald M. Levy 1 BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, USA 2 Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA 3 Department of Physics & Astronomy, Rutgers University, Piscataway, New Jersey, USA ∗ E-mail: Corresponding [email protected]
منابع مشابه
Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease
HIV protease, an aspartyl protease crucial to the life cycle of HIV, is the target of many drug development programs. Though many protease inhibitors are on the market, protease eventually evades these drugs by mutating at a rapid pace and building drug resistance. The drug resistance mutations, called primary mutations, are often destabilizing to the enzyme and this loss of stability has to be...
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